Study finds sexual dimorphism in the development of vascular insulin resistance induced by lifestyle-causing obesity

A new study from the University of Missouri School of Medicine has demonstrated for the first time in humans that short-term lifestyle changes can disrupt how blood vessels respond to insulin. It is also the first study to show

Vascular insulin resistance is a hallmark of obesity and type 2 diabetes, which contributes to vascular disease. The researchers examined vascular insulin resistance in 36 young, healthy men and women by reducing their physical activity for 10 days and reducing the number of steps per day from her 10,000 to her 5,000. . The participant also increased her intake of sugary drinks to her six cans of soda per day.

Premenopausal women have been found to have lower rates of insulin resistance and cardiovascular disease compared to men, but how men and women respond to reduced physical activity and increased dietary sugar in the short term. I wanted to see if they would respond to ”

Camila Manrique-Acevedo, MD, Associate Professor of Medicine

As a result, a sedentary lifestyle and high sugar intake have been associated with decreased insulin-stimulated blood flow in the legs and decreased levels of a protein called adropin, which regulates insulin sensitivity and is an important biomarker of cardiovascular disease. Only males were shown to cause decline.

“These findings highlight gender differences in the development of vascular insulin resistance induced by adopting a high-sugar, sedentary lifestyle,” said Manrique-Acevedo. To the best of our knowledge, this is the first evidence in humans that vascular insulin resistance can be caused by short-term adverse lifestyle changes, suggesting that changes in adropin-associated changes in the development of vascular insulin resistance have been demonstrated in humans. This is the first evidence of gender differences. Level.”

Manrique-Acevedo next wants to examine how long it takes to reverse these vascular and metabolic changes to more fully assess the impact of gender’s role in the development of vascular insulin resistance. Stated.

The entire MU research team consisted of Dr. Jaume Padilla, associate professor of nutrition and exercise physiology and co-director of the study. Luis Martinez-Lemus, DVM, PhD, Professor of Medical Pharmacology and Physiology, and R. Scott Rector, PhD, Associate Professor of Nutrition. Also included was a postdoctoral researcher, Dr. Rogelio Soares. Graduate students James A. Smith and Thomas Jurissen.

Their study, “Young Women Are Protected Against Vascular Insulin Resistance Caused by Adopting Obesity-Causing Lifestyles,” was recently published in the journal Endocrinology. Support for this study was provided in part by the National Institutes of Health and her VA Merit Grant. The content does not necessarily represent the official views of the funding agencies. The authors declare no potential conflicts of interest.

Manrique-Acevedo and her collaborators work at MU’s Roy Blunt NextGen Precision Health building. It connects government and industry leaders with innovators from the system’s four research universities, supporting statewide initiatives in pursuit of life-changing precision health advances. Bold by the University of Missouri System, her NextGen initiative highlights the potential of personalized healthcare and the impact of large-scale interdisciplinary collaboration.